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Mangosteen is leading compound for chemotherapy of
HIV infection


 1: Planta Med. 1998 Mar;64(2):97-109. Related Articles, Links Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection. Vlietinck AJ, De Bruyne T, Apers S, Pieters LA. Department of Pharmaceutical Sciences, University of Antwerp (UA), Belgium. This email address is being protected from spambots. You need JavaScript enabled to view it.
PMID: 9525100 [PubMed - indexed for MEDLINE]
Many compounds of plant origin have been identified that inhibit different stages in the replication cycle of human immunodeficiency virus (HIV):
icon virus adsorption: chromone alkaloids (schumannificine), isoquinoline alkaloids (michellamines), sulphated polysaccharides and polyphenolics, flavonoids, coumarins (glycocoumarin, licopyranocoumarin) phenolics (caffeic acid derivatives, galloyl acid derivatives, catechinic acid derivatives), tannins and triterpenes (glycyrrhizin and analogues, soyasaponin and analogues);
icon virus-cell fusion: lectins (mannoseand N-acetylglucosamine-specific) and triterpenes (betulinic acid and analogues);
icon reverse transcription: alkaloids (benzophenanthridines, protoberberines, isoquinolines, quinolines), coumarins (calanolides and analogues), flavonoids, phloroglucinols, lactones (protolichesterinic acid), tannins, iridoids (fulvoplumierin) and triterpenes;
icon integration: coumarins (3-substituted-4- hydroxycoumarins), depsidones, O-caffeoyl derivatives, lignans (arctigenin and analogues) and phenolics (curcumin);
icon translation: single chain ribosome inactivating proteins (SCRIP's);
icon proteolytic cleavage (protease inhibition): saponins (ursolic and maslinic acids), xanthones (mangostin and analogues) and coumarins;
icon glycosylation: alkaloids including indolizidines (castanospermine and analogues), piperidines (1-deoxynojirimicin and analogues) and pyrrolizidines (australine and analogues);
icon assembly/release: naphthodianthrones (hypericin and pseudohypericin), photosensitisers (terthiophenes and furoisocoumarins) and phospholipids.
   
Hiv imageThe target of action of several anti-HIV substances including alkaloids (O-demethylbuchenavianine, papaverine), polysaccharides (acemannan), lignans (intheriotherins, schisantherin), phenolics (gossypol, lignins, catechol dimers such as peltatols, naphthoquinones such as conocurvone) and saponins (celasdin B, Gleditsia and Gymnocladus saponins), has not been elucidated or does not fit in the proposed scheme.

Only a very few of these plant-derived anti-HIV products have been used in a limited number of patients suffering from AIDS viz. glycyrrhizin, papaverine, trichosanthin, castanospermine, N-butyl-1-deoxynojirimicin and acemannan.
Disclaimer
The Xanthones from the mangosteen have been shown in laboratory studies to be powerful Antioxidants, Anti-Inflammatories and to have other special properties. However, laboratory results do not guarantee that the same will happen in the human body. Mangosteen is a nutritious fruit not a drug, and no therapeutic claims are made for this product.