Mangosteen demonstrates potent inhibitory activity
against HIV-1

1: Planta Med. 1996 Aug;62(4):381-2. Related Articles, Links Active constituents against HIV-1 protease from Garcinia mangostana. Chen SX, Wan M, Loh BN.
PMID: 8792678 [PubMed - indexed for MEDLINE]

mangosteen-01The ethanol extract of Garcinia mangostana L. (Guttiferae) showed potent inhibitory activity against HIV-1 protease. The activity-guided purification of the extract resulted in the isolation of two active, known compounds.

The chemical structures of the isolated compounds were established by spectroscopic analyses as mangostin (IC50 = 5.12 +/- 0.41 microM) and gammamangostin (IC50 = 4.81 +/- 0.32 microM). The type of inhibition by both compounds is noncompetitive.
The Xanthones from the mangosteen have been shown in laboratory studies to be powerful Antioxidants, Anti-Inflammatories and to have other special properties. However, laboratory results do not guarantee that the same will happen in the human body. Mangosteen is a nutritious fruit not a drug, and no therapeutic claims are made for this product.